Walking initiated 20 minutes before the time of individual postprandial glucose peak reduces the glucose response in young men with overweight or obesity: A randomized crossover study

Xiaoyuan ZHANG, Waris WONGPIPIT, Fenghua SUN, Sinead SHERIDAN, Wendy Y J HUANG, Cindy H P SIT, Stephen H S WONG

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10 Citations (Scopus)

Abstract

Background: Although a single bout of postmeal exercise can lower postprandial glucose (PPG), its optimal timing remains unclear.
Objective: This study aimed to investigate the effect of exercise timing using an individualized approach on PPG in overweight or obese young men.
Methods: Twenty men [age: 23.0 ± 4.3 y; BMI (kg/m²): 27.4 ± 2.8] each completed three 240-min trials in a randomized order separated by 6–14 d: 1) sitting (SIT), 2) walking initiated at each participant's PPG-peak time (PPGP) (iP), and 3) walking initiated 20 min before the PPGP (20iP). For each participant, PPGP was predetermined using continuous glucose monitoring. Walking was performed at 50% maximal oxygen consumption for 30 min. Venous blood was collected at 15- and 30-min intervals for 0–120 min and 120–240 min, respectively. The primary outcome was plasma PPG. Generalized estimating equations were used for comparison between trials.
Results: Compared with SIT, the 4-h incremental AUCs (iAUCs) for plasma PPG (−0.6 mmol · L⁻¹ · h; P = 0.047) and insulin (−28.7%, P < 0.001) were reduced in 20iP only, and C-peptide concentrations were lower after iP (−14.9%, P = 0.001) and 20iP (−28.7%, P < 0.001). Plasma insulin (−11.1%, P = 0.006) and C-peptide (−8.3%, P = 0.012) were lower due to the 20iP compared with iP treatment. Finally, PPG reductions due to iP and 20iP occurred only in men with a BMI > 27.5 kg/m² (iP, −11.2%; 20iP, −14.7%; P = 0.047) and higher glucose iAUC values during SIT (iP, −25.5%; 20iP, −25.7%; P < 0.001).
Conclusions: Walking initiated 20 min before PPGP lowered PPG and plasma insulin and C-peptide concentrations in young men with overweight or obesity, in particular in those with high BMI or glucose iAUC values during SIT; it also lowered plasma insulin and C-peptide concentrations more effectively than did exercise initiated at PPGP. This trial was registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) as ChiCTR1900023175. Copyright © 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
Original languageEnglish
Pages (from-to)866-875
JournalThe Journal of Nutrition
Volume151
Issue number4
Early online date09 Feb 2021
DOIs
Publication statusPublished - Apr 2021

Citation

Zhang, X., Wongpipit, W., Sun, F., Sheridan, S., Huang, W. Y. J., Sit, C. H. P., & Wong, S. H. S. (2021). Walking initiated 20 minutes before the time of individual postprandial glucose peak reduces the glucose response in young men with overweight or obesity: A randomized crossover study. The Journal of Nutrition, 151(4), 866-875. doi: 10.1093/jn/nxaa420

Keywords

  • Postprandial glycemia
  • Postmeal exercise
  • Exercise timing
  • Individualized exercise
  • Postprandial glucose

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