Walking initiated 20 minutes before the time of individual postprandial glucose peak reduces the glucose response in young men with overweight or obesity: A randomized crossover study

Xiaoyuan ZHANG, Waris WONGPIPIT, Fenghua SUN, Sinead SHERIDAN, Wendy Y J HUANG, Cindy H P SIT, Stephen H S WONG

Research output: Contribution to journalArticlespeer-review

Abstract

Background: Although a single bout of postmeal exercise can lower postprandial glucose (PPG), its optimal timing remains unclear.
Objective: This study aimed to investigate the effect of exercise timing using an individualized approach on PPG in overweight or obese young men.
Methods: Twenty men [age: 23.0 ± 4.3 y; BMI (kg/m²): 27.4 ± 2.8] each completed three 240-min trials in a randomized order separated by 6–14 d: 1) sitting (SIT), 2) walking initiated at each participant's PPG-peak time (PPGP) (iP), and 3) walking initiated 20 min before the PPGP (20iP). For each participant, PPGP was predetermined using continuous glucose monitoring. Walking was performed at 50% maximal oxygen consumption for 30 min. Venous blood was collected at 15- and 30-min intervals for 0–120 min and 120–240 min, respectively. The primary outcome was plasma PPG. Generalized estimating equations were used for comparison between trials.
Results: Compared with SIT, the 4-h incremental AUCs (iAUCs) for plasma PPG (−0.6 mmol · L⁻¹ · h; P = 0.047) and insulin (−28.7%, P < 0.001) were reduced in 20iP only, and C-peptide concentrations were lower after iP (−14.9%, P = 0.001) and 20iP (−28.7%, P < 0.001). Plasma insulin (−11.1%, P = 0.006) and C-peptide (−8.3%, P = 0.012) were lower due to the 20iP compared with iP treatment. Finally, PPG reductions due to iP and 20iP occurred only in men with a BMI > 27.5 kg/m² (iP, −11.2%; 20iP, −14.7%; P = 0.047) and higher glucose iAUC values during SIT (iP, −25.5%; 20iP, −25.7%; P < 0.001).
Conclusions: Walking initiated 20 min before PPGP lowered PPG and plasma insulin and C-peptide concentrations in young men with overweight or obesity, in particular in those with high BMI or glucose iAUC values during SIT; it also lowered plasma insulin and C-peptide concentrations more effectively than did exercise initiated at PPGP. This trial was registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) as ChiCTR1900023175. Copyright © 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
Original languageEnglish
Pages (from-to)866-875
JournalThe Journal of Nutrition
Volume151
Issue number4
Early online date09 Feb 2021
DOIs
Publication statusPublished - Apr 2021

Citation

Zhang, X., Wongpipit, W., Sun, F., Sheridan, S., Huang, W. Y. J., Sit, C. H. P., & Wong, S. H. S. (2021). Walking initiated 20 minutes before the time of individual postprandial glucose peak reduces the glucose response in young men with overweight or obesity: A randomized crossover study. The Journal of Nutrition, 151(4), 866-875. doi: 10.1093/jn/nxaa420

Keywords

  • Postprandial glycemia
  • Postmeal exercise
  • Exercise timing
  • Individualized exercise
  • Postprandial glucose

Fingerprint Dive into the research topics of 'Walking initiated 20 minutes before the time of individual postprandial glucose peak reduces the glucose response in young men with overweight or obesity: A randomized crossover study'. Together they form a unique fingerprint.