Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish

Lizhu TANG; Shiwen SONG; Chenyan  HU; Chung Wah James LAM; Mengyuan LIU; Bingsheng ZHOU; Paul K. S. LAM; Lianguo CHEN

doi:10.1021/acs.chemrestox.0c00139

Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish

Lizhu TANG
, Shiwen SONG
, Chenyan HU
, Chung Wah James LAM
, Mengyuan LIU
, Bingsheng ZHOU
, Paul K. S. LAM
, Lianguo CHEN

Department of Science and Environmental Studies (SES)

Research output: Contribution to journal › Articles › peer-review

13 Citations (Scopus)

Abstract

The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants. Copyright © 2020 American Chemical Society.

Original language	English
Pages (from-to)	1605-1608
Journal	Chemical Research in Toxicology
Volume	33
Issue number	7
Early online date	May 2020
DOIs	https://doi.org/10.1021/acs.chemrestox.0c00139
Publication status	Published - 2020

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title = "Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish",

abstract = "The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants. Copyright {\textcopyright} 2020 American Chemical Society.",

author = "Lizhu TANG and Shiwen SONG and Chenyan HU and LAM, \{Chung Wah James\} and Mengyuan LIU and Bingsheng ZHOU and LAM, \{Paul K. S.\} and Lianguo CHEN",

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doi = "10.1021/acs.chemrestox.0c00139",

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AU - TANG, Lizhu

AU - SONG, Shiwen

AU - HU, Chenyan

AU - LAM, Chung Wah James

AU - LIU, Mengyuan

AU - ZHOU, Bingsheng

AU - LAM, Paul K. S.

AU - CHEN, Lianguo

PY - 2020

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DO - 10.1021/acs.chemrestox.0c00139

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SP - 1605

EP - 1608

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

IS - 7

ER -

Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish

Abstract

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