Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish

Lizhu TANG, Shiwen SONG, Chenyan HU, Chung Wah James LAM, Mengyuan LIU, Bingsheng ZHOU, Paul K. S. LAM, Lianguo CHEN

Research output: Contribution to journalArticles

Abstract

The present study exposed adult zebrafish to 0, 10, and 100 μg/L perfluorobutanesulfonate (PFBS) with or without dietary supplement of probiotic Lactobacillus rhamnosus. Interaction between probiotic and PFBS on sex endocrine and reproduction was investigated. It was striking to find that PFBS and probiotic coexposures almost ceased the fecundity, which was accompanied by disturbances in sex hormones and oocyte maturation in females. In contrast, probiotic additive efficiently antagonized the estrogenic activity of PFBS in males. For the first time, this study reported that probiotic heavily depended on sex to modulate the endocrine disruption and reproductive toxicity of aquatic pollutants. Copyright © 2020 American Chemical Society.
Original languageEnglish
Pages (from-to)1605-1608
JournalChemical Research in Toxicology
Volume33
Issue number7
Early online dateMay 2020
DOIs
Publication statusPublished - 2020

Citation

Tang, L., Song, S., Hu, C., Lam, J. C. W., Liu, M., Zhou, B., . . . Chen, L. (2020). Unexpected observations: Probiotic administration greatly aggravates the reproductive toxicity of perfluorobutanesulfonate in zebrafish. Chemical Research in Toxicology, 33(7), 1605-1608. doi: 10.1021/acs.chemrestox.0c00139

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