Toxicity of metal oxide nanoparticles: Mechanisms, characterization, and avoiding experimental artefacts

Aleksandra B. DJURIŠIĆ, Yu Hang LEUNG, Alan M. C. NG, Xiao Ying XU, Patrick K. H. LEE, Natalie DEGGER, Shiu Sun Rudolf WU

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169 Citations (Scopus)

Abstract

Metal oxide nanomaterials are widely used in practical applications and represent a class of nanomaterials with the highest global annual production. Many of those, such as TiO 2 and ZnO, are generally considered non-toxic due to the lack of toxicity of the bulk material. However, these materials typically exhibit toxicity to bacteria and fungi, and there have been emerging concerns about their ecotoxicity effects. The understanding of the toxicity mechanisms is incomplete, with different studies often reporting contradictory results. The relationship between the material properties and toxicity appears to be complex and diiffi cult to understand, which is partly due to incomplete characterization of the nanomaterial, and possibly due to experimental artefacts in the characterization of the nanomaterial and/or its interactions with living organisms. This review discusses the comprehensive characterization of metal oxide nanomaterials and the mechanisms of their toxicity. Copyright © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)26-44
JournalSmall
Volume11
Issue number1
DOIs
Publication statusPublished - 2015

Citation

Djurišić, A. B., Leung, Y. H., Ng, A. M. C., Xu, X. Y., Lee, P. K. H., Degger, N., & Wu, R. S. S. (2015). Toxicity of metal oxide nanoparticles: Mechanisms, characterization, and avoiding experimental artefacts. Small, 11(1), 26-44. doi: 10.1002/smll.201303947

Keywords

  • Nanomaterials
  • Nanoparticles
  • Metal oxides
  • Toxicity
  • Antibacterial activity
  • Nanoparticle toxicity

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