The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: A critical review of recent progress

Wenhui QIU, Hongyan ZHAN, Jiaqi HU, Ting ZHANG, Hai XU, Ming Hung WONG, Bentuo XU, Chunmiao ZHENG

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26 Citations (Scopus)

Abstract

Bisphenol S (BPS) has been introduced into the industry as a safer alternative to bisphenol A (BPA). The distribution of BPS has recently become an important issue worldwide, but investigations on the toxicity and mechanisms of BPS remain limited. A review of the literature reveals that BPS has widespread presence in environmental media, such as indoor dust, surface water, sediments, and sewage sludge. It has been detected in plants, paper products, some food items, and even in the human body. In addition, compared to BPA, BPS has a lower acute toxicity, similar or less endocrine disruption, similar neurotoxicity and immunotoxicity, and lower reproductive and developmental toxicity. The mechanisms underlying BPS toxicity may be related to the chemical properties of BPS in the human body, including interactions with estrogen receptors, and binding to DNA and some proteins, subsequently including exerting oxidative stress. However, further investigation on the potential risks of BPS to humans and its mechanisms of toxicity should be conducted to better understand and control the risks of such novel chemicals. Copyright © 2019 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)192-202
JournalEcotoxicology and Environmental Safety
Volume173
Early online dateFeb 2019
DOIs
Publication statusPublished - May 2019

Citation

Qiu, W., Zhan, H., Hu, J., Zhang, T., Xu, H., Wong, M., . . . Zheng, C. (2019). The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: A critical review of recent progress. Ecotoxicology and Environmental Safety, 173, 192-202. doi: 10.1016/j.ecoenv.2019.01.114

Keywords

  • Bisphenol S
  • Occurrence in environment
  • Human exposure
  • Toxicity mechanism
  • Estrogen receptor

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