The antiangiogenic and antitumor effects of scoparasin B in non-small-cell lung cancer

Kaili LIN, Lijuan HUANG, Yu ZHANG, Minshan CHEN, Zhan LI, Kin Lam Ken YUNG, Sha LV, Qianrong PAN, Weisong ZHANG, Jijun FU, Wanshan LI, Qiudi DENG

Research output: Contribution to journalArticlespeer-review

2 Citations (Scopus)

Abstract

Angiogenesis and vasculogenic mimicry (VM) are crucial for the growth and metastasis of non-small-cell lung cancer (NSCLC). Most tumor angiogenesis inhibitors mainly target endothelial cell-mediated angiogenesis, ignoring tumor-cell-mediated VM and frequently leading to tumor recurrence and metastasis. Thus, development of bioactive molecules interfering with both tumor angiogenesis and VM is necessary. Identifying novel angiogenesis inhibitors from natural products is a promising strategy. Scoparasin B, a pimarane diterpene extracted from a marine-derived fungus, Eutypella sp. F0219, has an antibacterial effect. However, its effect on angiogenesis and VM remains unexplored. In this study, we first certified that scoparasin B showed a strong inhibition effect on angiogenesis and the VM process in vitro and ex vivo. Moreover, scoparasin B prominently impeded tumor growth, angiogenesis, and VM in an NCI-H1299 xenograft model. Further study revealed that scoparasin B restrained tumor angiogenesis and VM by reducing the VEGF-A level and suppressing the VEGF-A/VEGFR2 signaling pathway. This study first demonstrated scoparasin B inhibited tumor angiogenesis, VM, and tumor growth of NSCLC and revealed its underlying mechanism. These new findings further support the potential of scoparasin B as a novel angiogenesis inhibitor and give a hint for further exploring potential angiogenesis inhibitors from natural products. Copyright © 2023 American Chemical Society and American Society of Pharmacognosy.

Original languageEnglish
Pages (from-to)368-379
JournalJournal of Natural Products
Volume86
Issue number2
Early online dateJan 2023
DOIs
Publication statusPublished - Feb 2023

Citation

Lin, K., Huang, L., Zhang, Y., Chen, M., Li, Z., Yung, K. K. L., Lv, S., Pan, Q., Zhang, W., Fu, J., Li, W., & Deng, Q. (2023). The antiangiogenic and antitumor effects of scoparasin B in non-small-cell lung cancer. Journal of Natural Products, 86(2), 368-379. https://doi.org/10.1021/acs.jnatprod.2c00979

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