Tenuigenin ameliorates cognitive dysfunction in Alzheimer's disease via hippocampal neurogenesis enhancement

Kaili LIN, Zhu ZHANG, Zhang ZHANG, Wenjun DING, Peili ZHU, Ying WANG, Xiaoli JIANG, Bin LIU, Kin Lam Ken YUNG, Shiqing ZHANG

Research output: Contribution to journalArticlespeer-review

Abstract

A promising strategy for treating Alzheimer's disease (AD) is hippocampal neurogenesis enhancement. Tenuigenin (TEN) is a bioactive compound extracted from Polygala tenuifolia that is widely used for treating amnesia in Chinese medicine. However, whether TEN is effective in treating AD through hippocampal neurogenesis is not fully clear. This study aimed to explore the pharmacologic effect and underlying mechanism of TEN on hippocampal neurogenesis and cognitive deficit amelioration in AD. In an in vivo study, TEN administration significantly ameliorated the cognitive decline in APP/PS1 transgenic AD mice via enhancement of hippocampal neurogenesis, which might be attributed to activation of the GSK-3β/β-catenin pathway. Furthermore, an in silico study suggested that TEN might be directly targeted to GSK-3β. Overall, TEN enhanced hippocampal neurogenesis and consequently ameliorated cognitive deficits via GSK-3β/β-catenin pathway activation, indicating that TEN might be a promising novel agent for AD treatment. Copyright © 2022 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)109-113
JournalPhytochemistry Letters
Volume51
Early online dateAug 2022
DOIs
Publication statusPublished - Oct 2022

Citation

Lin, K., Zhang, Z., Zhang, Z., Ding, W., Zhu, P., Wang, Y., Jiang, X., Liu, B., Yung, K. K.-L., & Zhang, S. (2022). Tenuigenin ameliorates cognitive dysfunction in Alzheimer's disease via hippocampal neurogenesis enhancement. Phytochemistry Letters, 51, 109-113. https://doi.org/10.1016/j.phytol.2022.08.005

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