Systemic lupus erythematosus patients with past neuropsychiatric involvement are associated with worse cognitive impairment: A longitudinal study

Y GAO, Esther Yuet Ying LAU, JHY WAN, CS LAU, MY MOK

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Longitudinal studies on cognitive impairment in patients with past history of neuropsychiatric lupus (NPSLE) are scant. In this study, NPSLE patients and matched disease and healthy controls were examined with a full battery of neuropsychological tests that covered eight cognitive domains at two time-points 12 months apart. Confounders, including depressive and anxiety symptoms, were measured by the Hospital Anxiety and Depression Scale. Eighteen NPSLE, 18 patients with systemic lupus erythematosus (SLE) who had no previous cerebral involvement (non-NPSLE) and 16 healthy subjects were recruited. NPSLE patients consistently reported more cognitive and anxiety symptoms than non-NPSLE patients over both time-points. NPSLE patients had significantly worse memory, simple and complex attention compared to non-NPSLE patients, among which memory remained significantly impaired after adjustment for confounders. NPSLE patients demonstrated a trend of higher raw scores of some neurocognitive tests upon re-evaluation over 12 months, but NPSLE patients did not demonstrate any practice effect. In conclusion, NPSLE patients had significantly worse and persistently impaired memory and learning deficits compared to non-NPSLE patients over the 12-month re-assessment period. Copyright © 2016 SAGE Publications.

Original languageEnglish
Pages (from-to)637-644
JournalLupus
Volume25
Issue number6
Early online date23 Dec 2015
DOIs
Publication statusPublished - 01 May 2016

Fingerprint

Systemic Lupus Erythematosus
Longitudinal Studies
Anxiety
Cognitive Dysfunction
Depression
Neurobehavioral Manifestations
Neuropsychological Tests
Memory Disorders
Healthy Volunteers
Learning

Citation

Gao, Y., Lau, E. Y. Y., Wan, J. H. Y., Lau, C. S., & Mok, M. Y. (2016). Systemic lupus erythematosus patients with past neuropsychiatric involvement are associated with worse cognitive impairment: A longitudinal study. Lupus, 25(6), 637-644. doi: 10.1177/0961203315624022

Keywords

  • Cognitive dysfunction
  • Mood disorder
  • Neuropsychiatric lupus
  • Systemic lupus erythematosus