Size fraction effect on phthalate esters accumulation, bioaccessibility and in vitro cytotoxicity of indoor/outdoor dust, and risk assessment of human exposure

Wei WANG, Fu-Yong WU, Min-Juan HUANG, Yuan KANG, Kwai Chung CHEUNG, Ming Hung WONG

Research output: Contribution to journalArticles

53 Citations (Scopus)

Abstract

Indoor and outdoor dusts from two urban centers in the Pearl River Delta, China, were analyzed and phthalate esters varied from 4.95 to 2220 μg g−1 in indoor dust, significantly higher than outdoor dust (1.70–869 μg g−1). Di-2-ethylhexyl phthalate (DEHP) was the dominant phthalate found and the highest distribution factor (DF) (1.56 ± 0.41) was noted in the <63 μm fraction (p < 0.05). In vitro cytotoxicity of dust extract on human T cell lymphoblast leukemic cell line (CCRF-CEM) indicated by Lethal Concentration 50 (LC50) decreased with particle size. The power model was found as a better fit for explaining the relationship between LC50 and phthalates (R2 = 0.46, p < 0.01). Bioaccessibility of phthalates in dust varied with different particle sizes, with the greatest bioaccessible fraction (2.49–38.6%) obtained in <63 μm. Risk assessment indicated that indoor dust ingestion accounted for the major source for DEHP exposure (81.4–96.4% of non-dietary exposure and 36.5% of total exposure), especially for toddlers. The cancer risks associated with DEHP via home dust were high (10−6–10−4), with 10% of houses estimated with unacceptable risks (>10−4). After corrected with the bioaccessibility of phthalates, the cancer risks of dust exposure were moderate (10−7–10−5). Copyright © 2013 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)753-762
JournalJournal of Hazardous Materials
Volume261
Early online dateMay 2013
DOIs
Publication statusPublished - Oct 2013

Citation

Wang, W., Wu, F.-Y., Huang, M.-J., Kang, Y., Cheung, K. C., & Wong, M. H. (2013). Size fraction effect on phthalate esters accumulation, bioaccessibility and in vitro cytotoxicity of indoor/outdoor dust, and risk assessment of human exposure. Journal of Hazardous Materials, 261, 753-762. doi: 10.1016/j.jhazmat.2013.04.039

Keywords

  • Phthalate esters
  • Size fraction effect
  • Cytotoxicity
  • Bioaccessibility
  • Risk assessment
  • Dust

Fingerprint Dive into the research topics of 'Size fraction effect on phthalate esters accumulation, bioaccessibility and in vitro cytotoxicity of indoor/outdoor dust, and risk assessment of human exposure'. Together they form a unique fingerprint.