We investigated the efficacy of a single vs. double steroid injections in the treatment of carpal tunnel syndrome (CTS) in a randomised double-blind controlled trial. Patients with idiopathic CTS were randomised into (i) one group receiving a baseline methylprednisolone acetate injection plus a saline injection 8 weeks later and (ii) a second group receiving methylprednisolone acetate injection at baseline and at 8 weeks. The primary outcome was the Global Symptom Score (GSS). Forty patients were recruited. By 40 weeks, the mean GSS improved from 25.6 to 14.1 in the single-injection group whereas from 26.7 to 12.6 in the reinjection group, but there was no significant difference in GSS between the two groups (p = 0.26). There were also no significant differences in terms of electrophysiological and functional outcomes. The results suggest that an additional steroid injection confers no added benefit to a single injection in terms of symptom relief. Copyright © 2005 Blackwell Publishing Ltd.
CitationWong, S. M., Hui, A. C. F., Lo, S. K., Chiu, J. H., Poon, W. F., & Wong, L. (2005). Single vs. two steroid injections for carpal tunnel syndrome: A randomised clinical trial. International Journal of Clinical Practice, 59(12), 1417-1421. doi: 10.1111/j.1368-5031.2005.00696.x
- Carpal tunnel syndrome
- Steroid injection
- Randomised controlled trial