Roles of glutamate receptors in Parkinson's disease

Zhu ZHANG, Shiqing ZHANG, Pengfei FU, Zhang ZHANG, Kaili LIN, Joshua Ka-Shun KO, Kin Lam Ken YUNG

Research output: Contribution to journalArticlespeer-review

101 Citations (Scopus)

Abstract

Parkinson’s disease is a progressive neurodegenerative disorder resulting from the degeneration of pigmented dopaminergic neurons in the substantia nigra pars compacta. It induces a series of functional modifications in the circuitry of the basal ganglia nuclei and leads to severe motor disturbances. The amino acid glutamate, as an excitatory neurotransmitter, plays a key role in the disruption of normal basal ganglia function regulated through the interaction with its receptor proteins. It has been proven that glutamate receptors participate in the modulation of neuronal excitability, transmitter release, and long-term synaptic plasticity, in addition to being related to the altered neurotransmission in Parkinson’s disease. Therefore, they are considered new targets for improving the therapeutic strategies used to treat Parkinson’s disease. In this review, we discuss the biological characteristics of these receptors and demonstrate the receptor-mediated neuroprotection in Parkinson’s disease. Pharmacological manipulation of these receptors during anti-Parkinsonian processes in both experimental studies and clinical trials are also summarized. Copyright © 2019 by the authors.

Original languageEnglish
Article number4391
JournalInternational Journal of Molecular Sciences
Volume20
Issue number18
DOIs
Publication statusPublished - Sept 2019

Citation

Zhang, Z., Zhang, S., Fu, P., Zhang, Z., Lin, K., Ko, J. K.-S., & Yung, K. K.-L. (2019). Roles of glutamate receptors in Parkinson's disease. International Journal of Molecular Sciences, 20(18), Article 4391. https://doi.org/10.3390/ijms20184391

Keywords

  • Parkinson’s disease
  • Glutamate receptors
  • NMDA receptor
  • mGluR4
  • mGluR5

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