Risk factors for incident dementia after stroke and transient ischemic attack

Jie YANG, Adrian WONG, Zhaolu WANG, Wenyan LIU, Wing Chi Lisa AU, Yunyun XIONG, Chiu Wing Winnie CHU, Yim Lung Eric LEUNG, Sirong CHEN, Christine Y. K. LAU, Yin Yan Anne CHAN, Yuk Lun Alexander LAU, Sin Ying Florence FAN, Howan Leung Vincent IP, Oi Yan Yannie SOO, Wai Hong Thomas LEUNG, Chi Lai HO, Ka Sing Lawrence WONG, Chung Tong Vincent MOK

Research output: Contribution to journalArticles

66 Citations (Scopus)

Abstract

Background: We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). Methods: We compared clinical and imaging features between patients with consecutive stroke/TIA with (n = 88) and without (n = 925) incident dementia at 3 to 6 months after a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those with (n = 37) and without (n = 13) incident dementia. Results: Age, history of diabetes mellitus, severity of white matter changes (WMCs), and medial temporal lobe atrophy (MTLA) were associated with incident dementia. Alzheimer's disease (AD)–like PiB retention was found in 29.7% and 7.7% (P = .032) of patients with and without incident dementia, respectively. Conclusions: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment. Copyright © 2015 The Alzheimer's Association.
Original languageEnglish
Pages (from-to)16-23
JournalAlzheimer's & Dementia
Volume11
Issue number1
Early online dateMar 2014
DOIs
Publication statusPublished - 2015

Citation

Yang, J., Wong, A., Wang, Z., Liu, W., Au, W. C. L., Xiong, Y., et al. (2015). Risk factors for incident dementia after stroke and transient ischemic attack. Alzheimer's & Dementia, 11(1), 16-23.

Keywords

  • Poststroke dementia
  • Vascular cognitive impairment
  • Brain atrophy
  • PiB-PET
  • Transient ischemic attack

Fingerprint Dive into the research topics of 'Risk factors for incident dementia after stroke and transient ischemic attack'. Together they form a unique fingerprint.