Abstract
Background: We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). Methods: We compared clinical and imaging features between patients with consecutive stroke/TIA with (n = 88) and without (n = 925) incident dementia at 3 to 6 months after a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those with (n = 37) and without (n = 13) incident dementia. Results: Age, history of diabetes mellitus, severity of white matter changes (WMCs), and medial temporal lobe atrophy (MTLA) were associated with incident dementia. Alzheimer's disease (AD)–like PiB retention was found in 29.7% and 7.7% (P = .032) of patients with and without incident dementia, respectively. Conclusions: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment. Copyright © 2015 The Alzheimer's Association.
Original language | English |
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Pages (from-to) | 16-23 |
Journal | Alzheimer's & Dementia |
Volume | 11 |
Issue number | 1 |
Early online date | Mar 2014 |
DOIs | |
Publication status | Published - 2015 |
Citation
Yang, J., Wong, A., Wang, Z., Liu, W., Au, W. C. L., Xiong, Y., et al. (2015). Risk factors for incident dementia after stroke and transient ischemic attack. Alzheimer's & Dementia, 11(1), 16-23. doi: 10.1016/j.jalz.2014.01.003Keywords
- Poststroke dementia
- Vascular cognitive impairment
- Brain atrophy
- PiB-PET
- Transient ischemic attack