Resting-state abnormalities in amnestic mild cognitive impairment: A meta-analysis

Kwok Wai LAU, Mei Kei LEUNG, Tatia Mei Chun LEE, Andrew Chi Kin LAW

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18 Citations (Scopus)

Abstract

Amnestic mild cognitive impairment (aMCI) is a prodromal stage of Alzheimer’s disease (AD). As no effective drug can cure AD, early diagnosis and intervention for aMCI are urgently needed. The standard diagnostic procedure for aMCI primarily relies on subjective neuropsychological examinations that require the judgment of experienced clinicians. The development of other objective and reliable aMCI markers, such as neural markers, is therefore required. Previous neuroimaging findings revealed various abnormalities in resting-state activity in MCI patients, but the findings have been inconsistent. The current study provides an updated activation likelihood estimation meta-analysis of resting-state functional magnetic resonance imaging (fMRI) data on aMCI. The authors searched on the MEDLINE/PubMed databases for whole-brain resting-state fMRI studies on aMCI published until March 2015. We included 21 whole-brain resting-state fMRI studies that reported a total of 156 distinct foci. Significant regional resting-state differences were consistently found in aMCI patients relative to controls, including the posterior cingulate cortex, right angular gyrus, right parahippocampal gyrus, left fusiform gyrus, left supramarginal gyrus and bilateral middle temporal gyri. Our findings support that abnormalities in resting-state activities of these regions may serve as neuroimaging markers for aMCI. Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Original languageEnglish
Article numbere790
JournalTranslational Psychiatry
Volume6
DOIs
Publication statusPublished - 2016

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Meta-Analysis
Parietal Lobe
Magnetic Resonance Imaging
Temporal Lobe
Neuroimaging
Alzheimer Disease
Prodromal Symptoms
Parahippocampal Gyrus
Cognitive Dysfunction
Gyrus Cinguli
Brain
PubMed
MEDLINE
Early Diagnosis
Databases
Pharmaceutical Preparations

Citation

Lau, W. K. W., Leung, M.-K., Lee, T. M. C., & Law, A. C. K. (2016). Resting-state abnormalities in amnestic mild cognitive impairment: A meta-analysis. Translational Psychiatry, 6. Retrieved from http://dx.doi.org/10.1038/tp.2016.55

Keywords

  • Diagnostic markers
  • Neuroscience