Quality-of-life measurement in patients undergoing radiation therapy for head and neck cancer: A Hong Kong experience

Phoebe S. Y. LO, Sing Kai LO, Michael C. F. TONG, Peter K. M. KU, Sing Fai LEUNG, C. Andrew VAN HASSELT

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6 Citations (Scopus)

Abstract

The aims of this study are (1) to establish a reliable and valid quality-of-life (QOL) questionnaire for Chinese patients with head and neck (H&N) cancer who are treated with radiation therapy and (2) to evaluate the impact of the immediate side effects of treatment on the QOL of these patients. The 39-item "Quality of Life Radiation Therapy Instrument with Head and Neck Companion Module" (QQL-RTl/

H&N) was translated into Chinese. In the reliability evaluation phase (study module 1), the questionnaire was administered twice to 36 H&N cancer patients, 7 days apart, during the second and third week of radiation therapy. In the validity evaluation phase (study module 2), 138 patients completed the QOL-RTVH&N before starting and at the end of radiation therapy. Sixty-nine of these 138 patients also completed the QOL-RTI/
H&N during the second week of their radiation therapy, at the same time as completing the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) questionnaire. Cronbach alpha coefficients were 0.88 for the general-tool QOL-RTl and 0.90 for the H&N subscale. Test-retest reliability was satisfactory with intraclass correlation coefficients of 0.89 for the general-tool QOL-RTl and 0.75 for the H&N subscale. The instrument can discriminate between patients with stage I or II disease and those with stage 111 or IV disease (P < .05). Concurrent validity was established by the good agreement with the FACT-H&N (r = 0.86, P < .001). A highly significant deterioration was in the QOL from the baseline to the end of treatment (mean difference for general tool = 1.95, P < .001; mean difference for H&N subscale = 4.85, P < .001). The Chinese QOL-RTl/
H&N is a reliable and valid tool for determining the QOL in H&N cancer patients receiving radiation therapy. The immediate side effects of treatment had a significantly negative impact on the patients' QOL. The impact was relatively large for the functional and treatment-site aspects. Copyright © 2004 American Academy of Medical Administrators.
Original languageEnglish
Pages (from-to)13-23
Journal Journal of Oncology Management
Volume13
Issue number6
Publication statusPublished - 2004

Citation

Lo, P. S. Y., Lo, S. K., Tong, M. C. F., Ku, P. K. M., Leung, S. F., & Van Hasselt, C. A. (2004). Quality-of-life measurement in patients undergoing radiation therapy for head and neck cancer: A Hong Kong experience. Journal of Oncology Management, 13(6), 13-23.

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