Polyphyllin II induces protective autophagy and apoptosis via inhibiting PI3K/AKT/mTOR and STAT3 signaling in colorectal cancer cells

Keyphrases

• Apoptosis 100%
• PI3K-AKT-mTOR Signaling 100%
• Colorectal Cancer Cells 100%
• STAT3 Signaling 100%
• Protective Autophagy 100%
• Polyphyllin II 100%
• Protein Level 16%
• Mammalian Target of Rapamycin (mTOR) 16%
• HCT116 Cells 16%
• Anti-colorectal Cancer 16%
• Cancer Effects 16%
• P-STAT3 16%
• Cytotoxicity 8%
• Colorectal Cancer 8%
• Tumor Growth 8%
• Mechanism of Action 8%
• Induced Apoptosis 8%
• Cell Cycle Arrest 8%
• Western Blotting 8%
• Cancer Cells 8%
• Cancer Mechanisms 8%
• Autophagy 8%
• Anticancer Activity 8%
• Therapeutic Agents 8%
• M Phase 8%
• Nude Mice 8%
• Janus Kinase 2 (JAK2) 8%
• Steroidal Saponins 8%
• HCT116 8%
• Phospho-Akt 8%
• STAT3 Inhibitor 8%
• Xenograft 8%
• SW620 Cells 8%
• Rhizoma Paridis 8%
• Phospho-Src 8%
• Overactivation 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Colorectal Cancer 100%
• Malignant Neoplasm 33%
• Tumor Growth 16%
• Cytotoxicity 16%
• Western Blot 16%
• Saponin 16%
• Nude Mouse 16%
• Janus Kinase 16%