In the past three decades, “policy entrepreneurship” has emerged as a key analytical concept helping to explain institutional and policy change. Despite this, however, the literature on policy entrepreneurship remains theoretically vexed, producing limited theoretical knowledge or explanatory models able to draw firm conclusions. Theory building on policy and institutional change, for example, how policy entrepreneurs institute and navigate change agendas, using what tools, strategies, resources, and capacities remains opaque. This is especially the case in developing country contexts, where most analytical investigation of policy entrepreneurship has addressed “first world” case examples. This special issue seeks to address this analytical gap in the literature, focusing on cases specific to developing country contexts, deepening our empirical knowledge of policy entrepreneurship in developing countries, but also exploring theoretical and conceptual debates as they relate to developing countries. Copyright © 2020 John Wiley & Sons, Ltd.