PM₂.₅ exposure suppresses dendritic maturation in subgranular zone in aged rats

Lewis CHENG, Kwok Wai LAU, Kin Hung Timothy FUNG, Benson Wui Man LAU, Bolton K. H. CHAU, Yutong LIANG, Zhe WANG, Kwok Fai SO, Tao WANG, Chetwyn Chi Hin CHAN, Tatia Mei Chun LEE

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4 Citations (Scopus)

Abstract

Detrimental effects of long-term inhalation of fine particulate matter (PM₂.₅) on the pulmonary and cardiovascular systems have been widely reported. Recent studies have shown that exposure to PM₂.₅ also causes adverse neurocognitive effects. This study investigates the effects of inhaled ammonium sulfate, which is a major compound of inorganic air pollutants in PM₂.₅, on adult neurogenesis in aged Sprague-Dawley rats. A total of 20 rats were randomly assigned to experimental (n = 10) and control (n = 10) conditions, wherein they were exposed to either ammonium sulfate or sham air for 2 h per day and for 28 consecutive days. It was observed that ammonium sulfate inhibited the maturation process and diminished dendritic complexity of immature neurons in the subgranular zone (SGZ) of the hippocampus significantly, although the number of neural stem cells or the rates of differentiation were comparable between the two groups. Our findings provide clear evidence on the direct relationship between air quality and advantageous neurogenesis. Exposure to PM leads to specific adverse effects on the maturation process during neurogenesis. Copyright © 2017 The Author(s). This article is published with open access at Springerlink.com
Original languageEnglish
Pages (from-to)50-57
JournalNeurotoxicity Research
Volume32
Issue number1
Early online dateMar 2017
DOIs
Publication statusPublished - 2017

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Particulate Matter
Neurogenesis
Ammonium Sulfate
Rats
Air
Cardiovascular system
Air Pollutants
Neural Stem Cells
Cardiovascular System
Stem cells
Air quality
Inhalation
Neurons
Sprague Dawley Rats
Hippocampus
Lung

Citation

Cheng, L., Lau, W. K. W., Fung, T. K. H., Lau, B. W. M., Chau, B. K. H., Liang, Y., . . . Lee, T. M. C. (2017). PM₂.₅ exposure suppresses dendritic maturation in subgranular zone in aged rats. Neurotoxicity Research, 32(1), 50-57. doi: 10.1007/s12640-017-9710-4

Keywords

  • Fine particulate matter
  • Neurogenesis
  • Ammonium sulfate
  • Dendritic complexity
  • Air pollution