Photoresponsive surface molecularly imprinted polymer on ZnO nanorods for uric acid detection in physiological fluids

Qian TANG, Zai-yong LI, Yu-bo WEI, Xia YANG, Lan-tao LIU, Cheng-Bin GONG, Xue-bing MA, Michael Hon Wah LAM, Cheuk Fai Stephen CHOW

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22 Citations (Scopus)

Abstract

A photoresponsive surface molecularly imprinted polymer for uric acid in physiological fluids was fabricated through a facile and effective method using bio-safe and biocompatible ZnO nanorods as a support. The strategy was carried out by introducing double bonds on the surface of the ZnO nanorods with 3-methacryloxypropyltrimethoxysilane. The surface molecularly imprinted polymer on ZnO nanorods was then prepared by surface polymerization using uric acid as template, water-soluble 5-[(4-(methacryloyloxy)phenyl)diazenyl]isophthalic acid as functional monomer, and triethanolamine trimethacryl ester as cross-linker. The surface molecularly imprinted polymer on ZnO nanorods showed good photoresponsive properties, high recognition ability, and fast binding kinetics toward uric acid, with a dissociation constant of 3.22 × 10⁻⁵ M in aqueous NaH₂PO₄ buffer at pH = 7.0 and a maximal adsorption capacity of 1.45 μmol g⁻¹. Upon alternate irradiation at 365 and 440 nm, the surface molecularly imprinted polymer on ZnO nanorods can quantitatively uptake and release uric acid. Copyright © 2016 Published by Elsevier B.V.
Original languageEnglish
Pages (from-to)33-39
JournalMaterials Science and Engineering: C
Volume66
Early online dateApr 2016
DOIs
Publication statusPublished - Sep 2016

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Uric Acid
Nanorods
Polymers
Fluids
Buffers
Esters
Monomers
Polymerization
Irradiation
Adsorption
Kinetics
Water

Citation

Tang, Q., Li, Z.-y., Wei, Y.-b., Yang, X., Liu, L.-t., Gong, C.-b., et al. (2016). Photoresponsive surface molecularly imprinted polymer on ZnO nanorods for uric acid detection in physiological fluids. Materials Science and Engineering: C, 66, 33-39.

Keywords

  • Teaching Development Grant (TDG)
  • Photoresponsive surface molecularly imprinted polymer
  • Uric acid
  • ZnO nanorods
  • Azobenzene