Photoresponsive hollow molecularly imprinted polymer for trace triamterene in biological samples

Cheng-Bin GONG, Yu-bo WEI, Lan-tao LIU, An-xun ZHENG, Yue-Hong YANG, Cheuk Fai Stephen CHOW, Qian TANG

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11 Citations (Scopus)

Abstract

This paper reports a photoresponsive hollow molecularly imprinted polymer for the determination of trace triamterene in biological sample. The photoresponsive hollow molecularly imprinted polymer was prepared on sacrificial silica microspheres via surface imprinting technique through atom transfer radical polymerization using a novel water-soluble azobenzene derivative, 4-[(4-methacryloyloxy)phenylazo]-3,5-dimethyl benzenesulfonic acid, as the functional monomer, and the sacrificial silica core was subsequently removed using HF etching method with 1.25 vol.% HF ethanolic solution. The morphologies and properties of the photoresponsive hollow molecularly imprinted polymer were further characterized and compared systematically with the corresponding photoresponsive surface molecularly imprinted polymer. Compared with surface imprinted polymer, the hollow material displayed higher binding capacity, better recognition ability, faster mass-transfer rate, and larger isomerization rate constants toward triamterene. The static binding properties of the imprinted materials were investigated under three irradiation conditions. The photoresponsive hollow molecularly imprinted polymer showed better specificity toward triamterene than its structural analogues (folic acid and caffeine) as examined by UV–vis and HPLC. The photoresponsive hollow molecularly imprinted polymer was utilized for the determination of trace triamterene in biological samples (human urine and serum) with advantages of simple sample pre-treatment, good recovery and good sensitivity. Copyright © 2017 Elsevier B.V.
Original languageEnglish
Pages (from-to)568-578
JournalMaterials Science and Engineering: C
Volume76
Early online dateMar 2017
DOIs
Publication statusPublished - Jul 2017

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Triamterene
Polymers
Silicon Dioxide
Atom transfer radical polymerization
Isomerization
Caffeine
Microspheres
Folic Acid
Etching
Rate constants
Mass transfer
Monomers
Irradiation
Derivatives
Recovery
Water

Bibliographical note

Gong, C.-B., Wei, Y.-B., Liu, L.-T., Zheng, A.-X., Yang, Y.-H., Chow, C.-F., et al. (2017). Photoresponsive hollow molecularly imprinted polymer for trace triamterene in biological samples. Materials Science and Engineering: C, 76, 568-578.

Keywords

  • Molecular imprinting technique
  • Photoresponsive hollow molecularly imprinted polymer
  • 4-[(4-Methacryloyloxy)phenylazo]-3,5-dimethyl benzenesulfonic acid
  • Triamterene
  • Anti-doping
  • Atom transfer radical polymerization
  • Biological samples