Photocontrolled extraction of uric acid from biological samples based on photoresponsive surface molecularly imprinted polymer microspheres

Cheng-Bin GONG, Zai-yong LI, Lan-tao LIU, Yu-bo WEI, Xia YANG, Cheuk Fai Stephen CHOW, Qian TANG

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We aim to develop novel photoresponsive surface molecularly imprinted polymer microspheres, a SiO₂₋surface molecularly imprinted polymer, for the photocontrolled extraction of uric acid from biological samples. The SiO₂₋surface molecularly imprinted polymer was prepared on silica microspheres by surface polymerization and characterized by using scanning electron microscopy, transmission electron microscopy, FTIR spectroscopy, thermogravimetric analysis, nitrogen adsorption–desorption analysis, and UV-visible spectroscopy. The SiO₂₋surface molecularly imprinted polymer microspheres showed a photocontrolled uptake and release of uric acid in NaH₂PO₄ buffer upon alternate irradiation at 365 and 440 nm. The SiO₂₋surface molecularly imprinted polymer microspheres were able to photocontrollably extract uric acid from complicated biological samples for concentration analysis with no significant interference encountered and it exhibited very good recognition ability and fast binding kinetics toward uric acid. Copyright © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)1396-1402
JournalJournal of Separation Science
Volume40
Issue number6
Early online dateJan 2017
DOIs
Publication statusPublished - Mar 2017

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Uric Acid
Microspheres
Polymers
Acids
Spectroscopy
Silicon Dioxide
Thermogravimetric analysis
Buffers
Nitrogen
Silica
Polymerization
Irradiation
Transmission electron microscopy
Scanning electron microscopy
Kinetics

Citation

Gong, C.-b., Li, Z.-y., Liu, L.-t., Wei, Y.-b., Yang, X., Chow, C.-f., et al. (2017). Photocontrolled extraction of uric acid from biological samples based on photoresponsive surface molecularly imprinted polymer microspheres. Journal of Separation Science, 40(6), 1396-1402.

Keywords

  • Molecular imprinting
  • Photocontrolled extraction
  • Surface molecularly imprinted polymers
  • Uric acid
  • Urine