Pesticides in human milk collected from Jinhua, China: Levels, influencing factors and health risk assessment

Lihong KUANG, Yizhong HOU, Fangqu HUANG, Aidi GUO, Wenjing DENG, Hongjie SUN, Liguo SHEN, Hongjun LIN, Huachang HONG

Research output: Contribution to journalArticlespeer-review

Abstract

In China, many studies have been carried out on pesticide residues in human milk, yet all of them are on organochlorine pesticides (OCPs) and mostly focused on large, economically developed cities. In this study, 27 pesticides including OCPs, pyrethroid pesticides (PYRs) and organophosphate pesticides (OPPs) in human milk were investigated in Jinhua, an inland and medium sized city in China. Method based on QuEChERS extraction and gas chromatography-mass spectrometer (GC-MS) determination was adopted to analyze the above pesticide residues. The influencing factors as well as the health risks were also evaluated. Results show that PYRs and OPPs in human milk samples were both undetectable. Regarding OCPs, the detection rate of hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH) and p,p'-dichlorodiphenyl-dichloroethylene (p,p'-DDE) were 83.6%, 36.4% and 58.2%, respectively, and their mean value were 29.4, 32.0 and 85.2 ng/g lipid, respectively. p,p'-DDE levels in human milk was significantly (p < 0.05) related to maternal age, but no association was detected between OCPs residues and other factors (living environment, dietary habit, living style, etc.), suggesting that OCPs in human milk in Jinhua were originated from nonspecific source. All estimated daily intake of pesticides (EDIpesticides) by infants were under the guideline suggested by Food and Agriculture Organization (FAO) and China Ministry of Health (CMH). Yet 9% of EDIsHCB and 16% of EDIsHCHs exceeded the guideline recommended by Health Canada. The associations between DDE residues and the delivery way as well as HCBs residues and the birth weight were seemly significant, yet the significance disappeared when consider age or gestational age as a cofounder, indicating that OCPs residue in mother's body in Jinhua has no obvious influence on fetus development and the delivery way. Copyright © 2020 Elsevier Inc.
Original languageEnglish
Article number111331
JournalEcotoxicology and Environmental Safety
Volume205
Early online date23 Sep 2020
DOIs
Publication statusPublished - 01 Dec 2020

Citation

Kuang, L., Hou, Y., Huang, F., Guo, A., Deng, W., Sun, H., . . . Hong, H. (2020). Pesticides in human milk collected from Jinhua, China: Levels, influencing factors and health risk assessment. Ecotoxicology and Environmental Safety, 205. Retrieved from https://doi.org/10.1016/j.ecoenv.2020.111331

Keywords

  • Pesticide residues
  • Human milk
  • Jinhua
  • Influencing factors
  • Health risk

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