Percutaneous penetration and metabolism of plasticizers by skin cells and its implication in dermal exposure to plasticizers by skin wipes

Weijian PAN, Diya ZENG, Na DING, Kesong LUO, Yu Bon MAN, Lixuan ZENG, Qiuyun ZHANG, Jiwen LUO, Yuan KANG

Research output: Contribution to journalArticles

Abstract

Numerous studies focused on the human exposure to plasticizers via dermal contact; however, the percutaneous penetration of plasticizers was seldom considered in exposure assessment. In the present study, skin wipes of palms, back-of-hands, and forehead were collected from 114 participants (ages: 18–27). There was no significant difference between the levels of phthalates from palms and back-of-hand, while all phthalates collected from the forehead were significantly higher than those from palms and back-of-hand (p < 0.001); di(2-ethylhexyl)phthalate levels were substantially higher than other detected phthalates followed by di(n-butyl)phthalate and di(isobutyl)phthalate (DiBP), and for alternative plasticizers, bis-2-ethylhexyl terephthalate levels were substantially higher than acetyltributyl citrate and bis-2-ethylhexyladipate. Skin permeation and metabolism of phthalates was assessed using human skin equivalent models. The permeability coefficient (kp) values of phthalates were significantly negatively correlated with their log octanol–water partition coefficient (log Kow), while a significantly positive correlation was found between the log Kow and the cumulative amounts of phthalates in the cells. The proportion of phthalate intake via dermal exposure to skin wipes ranges from 1.3% (for dimethyl phthalate) to 8.6% (for DiBP) and suggests that dermal absorption is a significant route for adult phthalate exposure. Copyright © 2020 American Chemical Society.
Original languageEnglish
Pages (from-to)10181-10190
JournalEnvironmental Science & Technology
Volume54
Issue number16
Early online dateJul 2020
DOIs
Publication statusPublished - Aug 2020

Citation

Pan, W., Zeng, D., Ding, N., Luo, K., Man, Y. B., Zeng, L., . . . Kang, Y. (2020). Percutaneous penetration and metabolism of plasticizers by skin cells and its implication in dermal exposure to plasticizers by skin wipes. Environmental Science & Technology, 54(16), 10181-10190. doi: 10.1021/acs.est.0c02455

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