The aim of this paper is to evaluate development of the non-invasive blood glucose measurement of near infrared (NIR) spectroscopy. The results showed that NIR spectroscopy might obtain glucose concentration of up to 200% difference under a same environmental condition with two months apart due to time and machine drifts. These effects can restrict the development of the non-invasive blood glucose measurement. Partial least square (PLS) regression was used, which showed advantage over using simple absorbance for glucose concentration. Non-invasive blood glucose measurement of health subjects (non-diabetics) was also investigated. The results showed that R correlation coefficient of prediction (Rp) was 0.48 and root mean square of prediction (rmsep) was 1.34 mmol/l. The error was mainly due to the physiological effect of different subjects. Copyright © 2010 Hindawi Publishing Corporation.
CitationLam, S. C. H., Chung, J. W. Y., Fan, K. L., & Wong, T. K. S. (2010). Non-invasive blood glucose measurement by near infrared spectroscopy: Machine drift, time drift and physiological effect. Journal of Spectroscopy, 24(6), 629-639. doi: 10.3233/SPE-2010-0485
- Machine drift
- Time drift
- Physiological effect
- Beer’s law