Neurotrophin receptor immunostaining in the vestibular nuclei of rats

F. X. ZHANG, C. H. LAI, S. K. LAI, Kin Lam Ken YUNG, D. K. Y. SHUM, Y. S. CHAN

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The distribution of high-affinity neurotrophin receptors in cells of the vestibular nuclear complex and its subnuclei of adult rats was examined. We noted a high density of tyrosine kinase (Trk) A- and B- and a lower density of TrkC-immunostained cells. In particular, long, intensely labelled immunostained-TrkB fibres formed networks in the neuropil. BothTrkA- and TrkB-immunostained cells were widely distributed in the lateral, medial and spinal vestibular nuclei, and were less frequently seen in the superior vestibular nucleus, x and y subnuclei. However, immunostaining for TrkC was weak in many cells within the vestibular nuclei. The widespread and abundant neuronal distribution of Trk receptors predicts that their associated neurotrophins exert significant effects on individual cells within the vestibular nuclei. Copyright © 2003 Lippincott Williams & Wilkins, Inc.

Original languageEnglish
Pages (from-to)851-855
Issue number6
Publication statusPublished - May 2003


Zhang, F. X., Lai, C. H., Lai, S. K., Yung, K. K. L., Shum, D. K. Y., & Chan, Y. S. (2003). Neurotrophin receptor immunostaining in the vestibular nuclei of rats. NeuroReport, 14(6), 851-855.


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