Neuropsychiatric disturbance after aneurysmal subarachnoid hemorrhage

Kwok Chu George WONG, Sandy Wai LAM, Sau Man Sandra CHAN, Mary LAI, Pui Pui Patty TSE, Chung Tong Vincent MOK, Wai Sang POON, Adrian WONG

Research output: Contribution to journalArticles

11 Citations (Scopus)

Abstract

Although aneurysmal subarachnoid hemorrhage (aSAH) accounts for only 3–5% of all strokes, a high degree of morbidity has been reported in this relatively young subset of patients. Neuropsychiatric disturbance has often been neglected in these reports. We aimed to investigate the pattern and pathological factors of chronic neuropsychiatric disturbance in aSAH patients. This cross-sectional observational four-center study was carried out in Hong Kong. Neuropsychiatric outcome (Neuropsychiatric Inventory Chinese Version [CNPI]) assessments were conducted cross-sectionally 1–4 years after ictus. Pathological factors considered were early brain injury as assessed by admission World Federation of Neurosurgical Societies grade, aneurysm treatment (clipping versus coiling), delayed cerebral infarction, and chronic hydrocephalus. One hundred and three aSAH patients’ spouses or caregivers completed the CNPI. Forty-two (41%) patients were reported to have one or more domain(s) of neuropsychiatric disturbance. Common neuropsychiatric disturbance domains included agitation/aggression, depression, apathy/indifference, irritability/lability, and appetite/eating disturbance. Chronic neuropsychiatric disturbance was associated with presence of chronic hydrocephalus. A subscore consisting of the five commonly affected domains seems to be a suitable tool for aSAH patients and should be further validated and replicated in future studies. Copyright © 2014 Elsevier Ltd.
Original languageEnglish
Pages (from-to)1695-1698
JournalJournal of Clinical Neuroscience
Volume21
Issue number10
Early online dateJun 2014
DOIs
Publication statusPublished - 2014

Citation

Wong, G. K. C., Lam, S. W., Chan, S. S. M., Lai, M., Tse, P. P. P., Mok, V., et al. (2014). Neuropsychiatric disturbance after aneurysmal subarachnoid hemorrhage. Journal of Clinical Neuroscience, 21(10), 1695-1698.

Keywords

  • Cerebral aneurysm
  • Neuropsychiatric disturbance
  • Stroke
  • Subarachnoid hemorrhage

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