Neuropathways of theory of mind in schizophrenia: A systematic review and meta-analysis

Yiting WENG, Jingxia LIN, Daniel Kwasi AHORSU, Hector W.H. TSANG

Research output: Contribution to journalArticlespeer-review

15 Citations (Scopus)

Abstract

Background: Social cognition is significantly associated with daily functioning in patients with schizophrenia. Its neural basis remains unknown. 

Methods: A systematic literature search was performed. Studies using imaging to measure theory of mind (ToM) in schizophrenia were identified. Imaging data were synthesized using the seed-based d mapping approach. Potential neuropathways were hypothesized based on the identified brain regions activated during ToM tasks. 

Results: A total of 25 studies were included in the present study. Compared with healthy people, patients with schizophrenia showed hyperactivations in superior longitudinal fasciculus II and hypoactivations in superior frontal gyrus, precuneus and cuneus, and precentral gyrus during ToM tasks. The primary brain regions involved in the potential neuropathways in schizophrenia were the middle temporal gyrus, superior and inferior frontal gyrus, and supplementary motor areas. 

Conclusion: Deactivated brain regions in schizophrenia overlapped with the default mode and salience networks. Our findings shed light on how to develop a diagnostic tool for deficits in social cognition using neuroimaging techniques and effective therapeutic interventions to rectify dysfunction in schizophrenia. Copyright © 2022 The Author(s). Published by Elsevier Ltd.

Original languageEnglish
Article number104625
JournalNeuroscience and Biobehavioral Reviews
Volume137
Early online dateMar 2022
DOIs
Publication statusPublished - Jun 2022

Citation

Weng, Y., Lin, J., Ahorsu, D. K., & Tsang, H. W. H. (2022). Neuropathways of theory of mind in schizophrenia: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 137. Retrieved from https://doi.org/10.1016/j.neubiorev.2022.104625

Keywords

  • Schizophrenia
  • Neuropathways
  • Social cognition
  • Theory of mind
  • Neuroimaging techniques

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