Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers

Susan L. AMES, Wai Ho Savio WONG, Antoine BECHARA, Christopher CAPPELLI, Mark DUST, Jerry L. GRENARD, Alan W. STACY

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Abstract

Inhibitory processes are highly relevant to behavioral control affecting decisions made daily. The Go/NoGo task is a common task used to tap basic inhibitory processes important in higher order executive functioning. The present study assessed neural correlates of response inhibition during performance of a Go/NoGo task in which NoGo signals or tests of inhibitory control consisted of images of beer bottles. Group comparisons were conducted between 21 heavy and 20 light drinkers, ranging in age from 18 to 22. Behaviorally, overall performance assessed with d-prime was significantly better among the lighter drinkers. On a neural level, the heavy drinkers showed significantly greater activity in the right dorsolateral prefrontal cortex, medial frontal cortex and cingulate relative to the light drinkers during the NoGo trials. These regions are implicated in reflective or control processing of information. Further, heavy drinkers showed significantly greater activity in the insula relative to light drinkers during NoGo trials, a neural region implicated in habit circuitry and tied to cue induced urges and emotional memories of physical effects of drugs. These results suggest that the heavier drinkers may have experienced increased working memorydemand and control efforts to withhold a response due to poorer inhibitory control from enhanced salienceof alcohol cues on the beer NoGo trials, which also engaged insula mediated effects. Copyright © 2014 Elsevier B.V.
Original languageEnglish
Pages (from-to)382-389
JournalBehavioural Brain Research
Volume274
Early online dateAug 2014
DOIs
Publication statusPublished - 2014

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Cues
Alcohols
Light
Frontal Lobe
Prefrontal Cortex
Automatic Data Processing
Habits
Pharmaceutical Preparations
Inhibition (Psychology)

Citation

Ames, S. L., Wong, S. W., Bechara, A., Cappelli, C., DUST, M., Grenard, J. L. et al. (2014). Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers. Behavioural Brain Research, 274, 382-389.

Keywords

  • Go/NoGo
  • Alcohol
  • Dorsolateral prefrontal
  • fMRI
  • Response inhibition