Nanotherapeutics in angiogenesis: Synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos

Jinping CHENG, Yan Juan GU, Yajun WANG, Shuk Han CHENG, Wing-Tak WONG

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26 Citations (Scopus)

Abstract

Background: Carbon nanotubes have shown broad potential in biomedical applications, given their unique mechanical, optical, and chemical properties. In this pilot study, carbon nanotubes have been explored as multimodal drug delivery vectors that facilitate antiangiogenic therapy in zebrafish embryos.
Methods: Three different agents, ie, an antiangiogenic binding site (cyclic arginine-glycine-aspartic acid), an antiangiogenic drug (thalidomide), and a tracking dye (rhodamine), were conjugated onto single-walled carbon nanotubes (SWCNT). The biodistribution, efficacy, and biocompatibility of these triple functionalized SWCNT were tested in mammalian cells and validated in transparent zebrafish embryos.
Results: Accumulation of SWCNT-associated nanoconjugates in blastoderm cells facilitated drug delivery applications. Mammalian cell xenograft assays demonstrated that these antiangiogenic SWCNT nanoconjugates specifically inhibited ectopic angiogenesis in the engrafted zebrafish embryos.
Conclusion: This study highlights the potential of using SWCNT for generating efficient nanotherapeutics. Copyright © 2011 Cheng et al, publisher and licensee Dove Medical Press Ltd.
Original languageEnglish
Pages (from-to)2007-2021
JournalInternational Journal of Nanomedicine
Volume6
Early online date15 Sep 2011
DOIs
Publication statusPublished - 2011

Citation

Cheng, J., Gu, Y.-J., Wang, Y., Cheng, S. H., & Wong, W.-T. (2011). Nanotherapeutics in angiogenesis: Synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos. International Journal of Nanomedicine, 6, 2007-2021. doi: 10.2147/ijn.s20145

Keywords

  • Carbon nanotubes
  • Drug delivery
  • Antiangiogenic therapy

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