Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate

Lianguo CHEN, Chenyan HU, Mirabelle M. P. TSUI, Teng WAN, Drew R. PETERSON, Qipeng SHI, Paul K. S. LAM, Doris W. T. AU, Chung Wah James LAM, Bingsheng ZHOU

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Accumulation of perfluorobutanesulfonate (PFBS) is frequently detected in biota, raising concerns about its ecological safety. However, hazardous effects of PFBS remain largely unexplored, especially for endocrine disrupting potency. In the present study, the multigenerational endocrine disrupting potential of PFBS was investigated by exposing F0 marine medaka eggs to PFBS at different concentrations (0, 1.0, 2.9, and 9.5 μg/L) until sexual maturity. The F1 and F2 generations were reared without continued exposure. Thyroidal disturbances were examined in all three generations. PFBS exposure decreased the levels of 3,5,3′-triiodothyronine (T3) in F0 female blood; however, it increased T3 or thyroxine (T4) levels in F0 brains, in which hyperthyroidism suppressed the local transcription of 5′-deiodinase 2 (Dio2). Obviously decreased T3 was transferred to F1 eggs, although the parental influences were reversed in F1 larvae. Delayed hatching was coupled with elevated T3 levels in F1 larvae. F1 adults showed comparable symptoms of thyroidal disruption with F0 adults. A slight recovery was noted in the F2 generation, although F2 larvae still exhibited thyroid disruption and synthesized excessive T4. Our results suggested that the offspring suffered more severe dysfunction of the thyroidal axis albeit without direct exposure. This study provided the first molecular insight about PFBS toxicology on the thyroid, beneficial to both human and environmental risk assessment. Copyright © 2018 American Chemical Society.
Original languageEnglish
Pages (from-to)4432-4439
JournalEnvironmental Science & Technology
Volume52
Issue number7
DOIs
Publication statusPublished - 2018

Fingerprint

endocrine system
Iodide Peroxidase
Triiodothyronine
Transcription
Thyroxine
Risk assessment
Life cycle
Brain
Blood
life cycle
larva
Recovery
egg
sexual maturity
toxicology
hatching
brain
biota
blood
safety

Citation

Chen, L., Hu, C., Tsui, M. M. P., Wan, T., Peterson, D. R., Shi, Q., . . . Zhou, B. (2018). Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate. Environmental Science & Technology, 52(7), 4432-4439. doi: 10.1021/acs.est.8b00700

Keywords

  • Alt. title: Multigenerational disruption of thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutane sulfonate (PFBS)