Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review

Idy S.C. MAN, Robin SHAO, Wai Kai HOU, Shirley Xin LI, Fiona Yan LIU, Maggy LEE, Yun Kwok WING, Suk-Yu YAU, Tatia M.C. LEE

Research output: Contribution to journalArticlespeer-review

14 Citations (Scopus)

Abstract

Humans experience multiple biological and emotional changes under acute stress. Adopting a multi-systemic approach, we summarized 61 studies on healthy people’s endocrinological, physiological, immunological and emotional responses to the Trier Social Stress Test. We found salivary cortisol and negative mood states were the most sensitive markers to acute stress and recovery. Biomarkers such as heart rate and salivary alpha-amylase also showed sensitivity to acute stress, but the numbers of studies were small. Other endocrinological (e.g., dehydroepiandrosterone), inflammatory (C-Reactive Protein, Interleukin-6) and physiological (e.g., skin conductance level) measures received modest support as acute stress markers. Salivary cortisol showed some associations with mood measures (e.g., state anxiety) during acute stress and recovery, and heart rate showed preliminary positive relationship with calmness ratings during response to TSST, but the overall evidence was mixed. While further research is needed, these findings provide updated and comprehensive knowledge on the integrated psychobiological response profiles to TSST. Copyright © 2022 The Authors.
Original languageEnglish
Article number101050
JournalFrontiers in Neuroendocrinology
Volume68
Early online dateNov 2022
DOIs
Publication statusPublished - Jan 2023

Citation

Man, I. S. C., Shao, R., Hou, W. K., Li, S. X., Liu, F. Y., Lee, M., . . . Lee, T. M. C. (2023). Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review. Frontiers in Neuroendocrinology, 68. Retrieved from https://doi.org/10.1016/j.yfrne.2022.101050

Keywords

  • Meta-analysis
  • Acute Stress
  • TSST
  • Biomarker
  • Cortisol
  • Emotion

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