Background and purpose: After aneurysmal subarachnoid hemorrhage (aSAH), cognitive impairment, even mild and relatively isolated, can be devastating, especially in working-age persons. The Montreal Cognitive Assessment (MoCA) is accepted as a valid screening tool for mild cognitive impairment due to cerebral ischaemia. Whether MoCA is independently associated with excellent outcome [a score of 0 on the modified Rankin Scale (mRS) or 18/18 on the Lawton Instrumental Activities of Daily Living (IADL) scale] 1 year after aSAH was assessed. Methods: Hong Kong Chinese aSAH patients were assessed prospectively by means of the MoCA, Mini-Mental State Examination (MMSE), mRS and IADL scale at 1 year. This multicenter prospective observational study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193). Results: In all, 194 patients completed the assessments at 1 year. After adjustment for age, both excellent IADL and mRS outcomes were associated with MoCA (OR 1.2, 95% CI 1.1–1.3, P < 0.001, and OR 1.1, 95% CI 1.0–1.2, P = 0.001, respectively). Conclusions: MoCA-assessed cognitive function is an important determinant for excellent outcomes after aSAH. Copyright © 2014 The Author(s) European Journal of Neurology © 2014 EFNS.
CitationWong, G. K. C., Lam, S. W., Wong, A., Lai, M., Siu, D., Poon, W. S., et al. (2014). MoCA-assessed cognitive function and excellent outcome after aneurysmal subarachnoid hemorrhage at 1 year. European Journal of Neurology, 21(5), 725-730.
- Subarachnoid hemorrhage
- Cerebral aneurysm
- Mini-mental state examination
- Montreal cognitive assessment