MiR-30a-5p regulates GLT-1 function via a PKCα-mediated ubiquitin degradation pathway in a mouse model of Parkinson’s disease

Keyphrases

• 1,2,3,6-Tetrahydropyridine 12%
• 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 12%
• 1-methyl-4-phenylpyridinium 12%
• Astrocytes 25%
• Astrogliosis 12%
• Copyright 12%
• Degradation Pathway 100%
• Glutamate Excitotoxicity 12%
• Glutamate Transporter 1 (GLT-1) 100%
• Glutamate Uptake 12%
• Immunofluorescence Labeling 12%
• Knockdown 25%
• Methyl 12%
• MicroRNA 12%
• MiR-30a-5p 100%
• Motor Deficits 12%
• Mouse Model 100%
• Parkinson's Disease 50%
• Parkinson's Disease Model 100%
• Pathological Changes 12%
• Phenyl 12%
• Putative Drug Targets 12%
• Reactive Microgliosis 12%
• RNA-based 12%
• Short Hairpin RNA (shRNA) 12%
• Ubiquitin-mediated Degradation 100%
• Ubiquitination 12%
• Western Blotting 12%

Neuroscience

• Astrocyte 33%
• Astrogliosis 16%
• Excitotoxicity 16%
• Gliosis 16%
• Glutamate Transporter 50%
• Glutamic Acid 33%
• In Vitro 16%
• In Vivo 16%
• MicroRNA 16%
• Parkinson's Disease 100%
• Small Hairpin RNA 16%
• Tetrahydropyridine 33%
• Treatment of Parkinson's Disease 16%
• Ubiquitin 100%
• Ubiquitination 16%
• Vesicular Glutamate Transporter 1 100%
• Western Blot 16%