Maternal adverse childhood experience and depression in relation with brain network development and behaviors in children: A longitudinal study

Han ZHANG, Ting Yat WONG, Birit F. P. BROEKMAN, Yap-Seng CHONG, Lynette P. SHEK, Peter D. GLUCKMAN, Kok Hian TAN, Michael J. MEANEY, Marielle V. FORTIER, Anqi QIU

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8 Citations (Scopus)

Abstract

Maternal childhood maltreatment and depression increase risks for the psychopathology of the offspring. This study employed a longitudinal dataset of mother-child dyads to investigate the developmental trajectories of brain functional networks and behaviors of children in relation with maternal childhood adverse experience and depression. Maternal childhood trauma was retrospectively assessed via childhood trauma questionnaire, whereas maternal depressive symptoms were prospectively evaluated during pregnancy and after delivery (n = 518). Child brain scans were acquired at age of 4.5, 6, and 7.5 years (n = 163) and behavioral problems were measured at 7.5 years using the Child Behavior Checklist. We found the functional connectivity of the language network with the sensorimotor, frontal, and attentional networks as a function of maternal adverse experience that interacted with sex and age. Girls exposed to mothers with depressive symptoms or childhood abuse showed the increased development of the functional connectivity of the language network with the visual networks, which was associated with social problems. Girls exposed to mothers with depressive symptoms showed the slower growth of the functional connectivity of the language network with the sensorimotor networks. Our findings, in a community sample, suggest the language network organization as neuroendophenotypes for maternal childhood trauma and depression. Copyright © 2021 The Author(s). Published by Oxford University Press.

Original languageEnglish
Pages (from-to)4233-4244
JournalCerebral Cortex
Volume31
Issue number9
Early online dateApr 2021
DOIs
Publication statusPublished - Sept 2021

Citation

Zhang, H., Wong, T.-Y., Broekman, B. F. P., Chong, Y.-S., Shek, L. P., Gluckman, P. D., Tan, K. H., Meaney, M. J., Fortier, M. V., & Qiu, A. (2021). Maternal adverse childhood experience and depression in relation with brain network development and behaviors in children: A longitudinal study. Cerebral Cortex, 31(9), 4233-4244. https://doi.org/10.1093/cercor/bhab081

Keywords

  • Childhood trauma
  • Maternal depression
  • Brain functional networks
  • Developmental trajectory
  • Resting-state functional MRI
  • Child behavior

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