Low levels of morning salivary α-amylase activity predict higher number of depressive symptoms in a community sample of children

Enrique Francisco MALDONADO, Eugenia FERNÁNDEZ, María Victoria TRIANES, Carmen ORTÍZ, Alfredo ENGUIX, Mari Anneli NISLIN

Research output: Contribution to journalArticles

Abstract

Models of the etiology of depressive disorders suggest that the onset of a depressive episode is the result of a complex phenomenon based on the interaction between genetic background, critical environmental factors such as life stressors and traumatic events, and the effects of neuroendocrine changes associated with the stress response. Numerous studies have highlighted the usefulness of morning cortisol (C) as a potential predictor of depressive episodes. The aim of this study was to compare the effectiveness of C, salivary alpha-amylase (sAA) activity/output, and the sAA/C ratio in predicting depressive symptoms in a community sample of 99 children aged 8-11 years old. Two saliva samples were obtained in the morning on two different school days. Teachers described their pupils' behavior by using the internalizing problems scales of the Teacher's Report Form (TRF) questionnaire. Our results indicate that, regardless of gender, the best predictor of depressive/withdrawal scores and overall internalizing scores on the TRF was lower mean morning levels of sAA activity. Hence, sAA could be proposed as a biological marker for the risk of developing a first episode of depressive illness in child samples. Copyright © 2018 Servicio de Publicaciones, Universidad de Murcia (Spain).
Original languageEnglish
Pages (from-to)224-232
JournalAnales de Psicologia
Volume34
Issue number2
DOIs
Publication statusPublished - 2018

Citation

Maldonado, E. F., Fernández, E., Trianes, M. V., Ortíz, C., Enguix, A., & Nislin, M. (2018). Low levels of morning salivary α-amylase activity predict higher number of depressive symptoms in a community sample of children. Anales de Psicologia, 34(2), 224-232. doi: 10.6018/analesps.34.2.289741

Keywords

  • Alpha-amylase
  • Cortisol
  • Depressive symptoms
  • Children
  • Observational descriptive study

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