Lie detection by functional magnetic resonance imaging

Tatia M.C. LEE, Ho-Ling LIU, Li-Hai TAN, Che Hin Chetwyn CHAN, Srikanth MAHANKALI, Ching-Mei FENG, Jinwen HOU, Peter T. FOX, Jia-Hong GAO

Research output: Contribution to journalArticlespeer-review

211 Citations (Scopus)


The accurate detection of deception or lying is a challenge to experts in many scientific disciplines. To investigate if specific cerebral activation characterized feigned memory impairment, six healthy male volunteers underwent functional magnetic resonance imaging with a block-design paradigm while they performed forced-choice memory tasks involving both simulated malingering and under normal control conditions. Malingering that demonstrated the existence and involvement of a prefrontal-parietal-sub-cortical circuit with feigned memory impairment produced distinct patterns of neural activation. Because astute liars feign memory impairment successfully in testing once they understand the design of the measure being employed, our study represents an extremely significant preliminary step towards the development of valid and sensitive methods for the detection of deception. Copyright © 2002 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)157-164
JournalHuman Brain Mapping
Issue number3
Publication statusPublished - Mar 2002


Lee, T. M. C., Liu, H.-L., Tan, L.-H., Chan, C. C. H., Mahankali, S., Feng, C.-M., . . . Gao, J.-H. (2002). Lie detection by functional magnetic resonance imaging. Human Brain Mapping, 15(3), 157-164. doi: 10.1002/hbm.10020


  • Mental processes
  • Lie detection
  • Malingering
  • Neuropsychology
  • Memory
  • Functional magnetic resonance imaging


Dive into the research topics of 'Lie detection by functional magnetic resonance imaging'. Together they form a unique fingerprint.