Aim: To assess interobserver reproducibility of major pathologic prognostic parameters in cutaneous melanoma.
Methods: Single hematoxylin and eosin-stained slides of 69 dermally invasive primary cutaneous melanomas were circulated among six pathologists with differing experience in the assessment of melanocytic tumors. The observers independently determined the tumor thickness, Clark level of invasion, ulcerative state, and TMR for each lesion. Intraclass correlation coefficients and kappa scores for multiple ratings per subject were calculated.
Results: The intraclass correlation coefficients were 0.96 for tumor thickness and 0.76 for TMR. The kappa scores were 0.83 for ulcerative state and 0.60 for Clark level. These results indicated excellent agreement among the pathologists for measurements of tumor thickness, ulcerative state, and TMR and fair to good agreement for Clark level.
Conclusions: Appropriately trained and experienced histopathologists can assess prognostically important features of melanomas accurately and reproducibly. Given our recent finding of the significance of TMR in determining prognosis, it is important that this feature be assessed by a standardized method and documented for all primary cutaneous melanomas. Copyright © 2003 Lippincott Williams & Wilkins, Inc.
CitationScolyer, R. A., Shaw, H. M., Thompson, J. F., Li, L.-X. L., Colman, M. H., Lo, S. K., . . . Stretch, J. R. (2003). Interobserver reproducibility of histopathologic prognostic variables in primary cutaneous melanomas. The American Journal of Surgical Pathology, 27(12), 1571-1576. doi: 10.1097/00000478-200312000-00011
- Mitotic rate
- Observer variation
- Quality control
- Kappa statistics