Increased frequency of apolipoprotein B signal peptide sp24/24 in patients with coronary artery disease: General allele survey in the population of Taiwan and comparison with Caucasians

J. H. WU, M. S. WEN, Sing Kai LO, M. S. CHERN

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Abstract

Apolipoprotein B (apoB) signal peptide (sp) polymorphism was characterized by polymerase chain reaction in blood samples of 58 coronary artery disease (CAD) patients and 319 control individuals of Chinese Han ethnic origin in Taiwan. In the CAD group, 77% of the observed alleles were sp27 (sp with 27 amino acids), and the remaining 23%sp24 (sp with 24 amino acids). The frequency distributions of the apoB sp allele in the control group were 0.81 for sp27 and 0.19 for sp24. The genotype distributions were 0.64 sp27/27, 0.26 sp27/24 and 0.10 sp24/24 in the CAD group; 0.64 sp27/27. 0.33 sp27/24 and 0.03 sp24/24 in the control group. The frequency of sp24/24 was significantly higher (p= 0.012) in the CAD group than in the control group. Several studies have shown that the frequency of sp24/24 is higher in hyperlipidemic than in normolipidemic groups. This marker is probably in linkage disequlibrium with some other atherogenic genes. Our study shows that the differences in both apoB signal peptide alleles and sp27/27 and sp27/24 genotype distributions are statistically significant between the Taiwanese and Caucasians. Copyright © 1994 Munksgaard.
Original languageEnglish
Pages (from-to)250-254
JournalClinical Genetics
Volume45
Issue number5
DOIs
Publication statusPublished - May 1994

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Apolipoproteins B
Protein Sorting Signals
Taiwan
Coronary Artery Disease
Alleles
Population
Control Groups
Genotype
Amino Acids
Surveys and Questionnaires
Polymerase Chain Reaction
Genes

Bibliographical note

Wu, J. H., Wen, M. S., Lo, S. K., & Chern, M. S. (1994). Increased frequency of apolipoprotein B signal peptide sp24/24 in patients with coronary artery disease: General allele survey in the population of Taiwan and comparison with Caucasians. Clinical Genetics, 45(5), 250-254. doi: 10.1111/j.1399-0004.1994.tb04150.x

Keywords

  • Allele frequency
  • Apolipoprotein B
  • Coronary artery disease
  • Signal peptide