Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses

Ziqing ZHU, You WANG, Kwok Wai LAU, Xinhua WEI, Yingjun LIU, Ruiwang HUANG, Ruibin ZHANG

Research output: Contribution to journalArticlespeer-review

2 Citations (Scopus)

Abstract

Disrupted whole-brain resting-state functional connectivity (RSFC) of the posterior cingulate (PCC) has been highlighted to associate with cognitive and affective dysfunction in major depressive disorder (MDD). However, prior findings showed certain inconsistency about the RSFC of the PCC in MDD. This study aims to investigate the aberrant RSFC of the PCC in MDD using anisotropic effect-size version of seed-based d mapping (AES-SDM). Web of Science and PubMed were searched for studies investigating PCC-based RSFC in MDD. A total of 17 studies, involving 804 patients and 724 healthy controls (HCs), fit our selection criteria. Additionally, to seek for the link between functional and structural differences, we did a meta-analysis on the studies in conjunction with voxel-based morphology (VBM) analysis. The PCC showed higher RSFC with the left middle temporal gyrus (MTG) and the right middle frontal gyrus (MFG), and lower RSFC with the left superior frontal gyrus (SFG) and the left precuneus in patients with MDD than HCs. Moreover, the meta-regression analysis revealed a negative correlation between the FC alteration of the right MFG with the PCC and depression severity. Notably, the left MTG and the left MFG demonstrated gray matter deviations in conjunction analysis. Our results indicated that the aberrant RSFC between the PCC and brain regions sub-serving cognitive control and emotional regulation in patients with MDD. And such functional alterations may have structural basis. These findings may underlie the mechanisms of deficits in cognitive control and emotional regulation of MDD. Copyright © 2022 The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Original languageEnglish
Pages (from-to)1538–1551
JournalBrain Imaging and Behavior
Volume16
Issue number4
Early online dateJan 2022
DOIs
Publication statusPublished - Aug 2022

Citation

Zhu, Z., Wang, Y., Lau, W. K. W., Wei, X., Liu, Y., Huang, R., & Zhang, R. (2022). Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses. Brain Imaging and Behavior, 16(4), 1538–1551. doi: 10.1007/s11682-022-00628-7

Keywords

  • Posterior cingulate
  • Resting-state functional connectivity
  • Meta-analysis

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