Hepatitis C virus infection facilitates gallstone formation

Te-Sheng CHANG, Sing Kai LO, Hueih-Yuan SHYR, Ji-Tseng FANG, Wei-Chen LEE, Dar-In TAI, I.-Shyan SHEEN, Deng-Yn LIN, Chia-Ming CHU, Yun-Fan LIAW

Research output: Contribution to journalArticlespeer-review

32 Citations (Scopus)


Background: Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection; and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis C virus infection.
Methods: Persons who received a general checkup in Chang Gung Memorial Hospital between 2000 and 2002 were included. All of them had hemogram, serum biochemistry, hepatitis B surface antigen, hepatitis C antibody and ultrasonography studies. The prevalence of gallbladder stone, bile duct stone and gallbladder polyp/cholesterolosis were compared in different viral infection groups.
Results: Of the 28 486 persons, 22 967 were negative for both hepatitis B surface antigen and hepatitis C antibody (group NBNC), 4152 were hepatitis B surface antigen carriers (broup B), 1195 were positive for hepatitis C antibody (group C), and 172 were positive for both markers. The 379 persons (1.3%) having had cholecystectomy were considered to have gallbladder stone at the time when cholecystectomy was done. Gallbladder stone was found in 6.0% persons of group NBNC, 5.4% in group B and 11.7% in group C. The prevalence of gallbladder stone in group C was found especially high for age groups 31-40 years and 61-70 years. The prevalence of bile duct stone was higher in group C (0.4%) than in group NBNC or B (both 0.1%). Stepwise logistic regression analysis showed that age, liver cirrhosis, body mass index, hepatitis C virus infection and gender were independent factors associated with gallbladder stone.
Conclusions: Hepatitis C virus infection facilitates gallstone formation. Copyright © 2005 Blackwell Publishing Asia Pty Ltd.
Original languageEnglish
Pages (from-to)1416-1421
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number9
Publication statusPublished - 2005


Chang, T.-S., Lo, S. K., Shyr, H.-Y., Fang, J.-T., Lee, W.-C., Tai, D.-I., . . . Liaw, Y.-F. (2005). Hepatitis C virus infection facilitates gallstone formation. Journal of Gastroenterology and Hepatology, 20(9), 1416-1421. doi: 10.1111/j.1440-1746.2005.03915.x


  • Gallbladder stone
  • General checkup
  • Hepatitis C virus
  • Prevalence


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