Haematological and immunological data of Chinese children infected with coronavirus disease 2019

Xiaoli XIONG, Gilbert T. CHUA, Shuiqing CHI, Mike Yat Wah KWAN, Wilfred Hing Sang WONG, Aifen ZHOU, Chi Chiu SHEK, Keith T.S. TUNG, Huan QIN, Rosa Sze Man WONG, Xue LI, Peng CHEN, Shuai LI, Celine S. CHUI, Winnie W.Y. TSO, Marco H.K. HO, Ian C.K. WONG, Godfrey C.F. CHAN, Yu Lung LAU, Kenneth K.Y. WONGPatrick H.Y. CHUNG, Hui LI, Paul K.H. TAM, Shao-Tao TANG, Patrick IP

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16 Citations (Scopus)

Abstract

Haematological and immunological data of children with COVID-19 infection is lacking. Between 21st January and 20th March 2020, 244 children who were confirmed to have COVID-19 infection and admitted to the Wuhan Children's Hospital, China were retrospectively reviewed. 193 children were considered as symptomatic, which was defined as having either the presence of clinical symptoms or the presence of CT thorax abnormalities. Their haematological and immunological profiles, including complete blood counts, lymphocyte subsets (T, B and NK cell counts), immunoglobulin (Ig) profiles (IgG, IgA and IgM) and cytokine profiles were analysed and compared between the symptomatic and asymptomatic groups. The median values and the interquartile ranges were calculated. Comparison was made using the Mann–Whitney U test. Children with symptomatic COVID-19 infection had significantly lower haemoglobin levels, but higher absolute lymphocyte and monocyte counts, IgG and IgA levels, as well as interleukin 6 (IL-6), IL-10, tumour necrosis factor alpha and interferon gamma levels. The obtained data will be utilized for further studies in comparing children and adults with COVID-19 infections in other parts of the world and with different severity. Copyright © 2020 The Authors. Published by Elsevier Inc.

Original languageEnglish
Article number105953
JournalData in Brief
Volume31
Early online dateJun 2020
DOIs
Publication statusPublished - Aug 2020

Citation

Xiong, X., Chua, G. T., Chi, S., Kwan, M. Y. W., Wong, W. H. S., Zhou, A., Shek, C. C., Tung, K. T. S., Qin, H., Wong, R. S., Li, X., Chen, P., Li, S., Chui, C. S., Tso, W. W. Y., Ho, M. H. K., Wong, I. C. K., Chan, G. C. F., Lau, Y. L., . . . & lp, P. (2020). Haematological and immunological data of Chinese children infected with coronavirus disease 2019. Data in Brief, 31, Article 105953. https://doi.org/10.1016/j.dib.2020.105953

Keywords

  • COVID-19
  • Children
  • Chinese
  • Lymphocyte subsets
  • Cytokines
  • Immunoglobulin

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