Gold-doxorubicin nanoconjugates for overcoming multidrug resistance

Yan Juan GU, Jinping CHENG, Cornelia Wing Yin MAN, Wing-Tak WONG, Shuk Han CHENG

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142 Citations (Scopus)

Abstract

Multidrug resistance (MDR) is a major clinical obstacle to the success of cancer chemotherapy. Here we developed a gold-doxorubicin (DOX) nanoconjugates system to overcome MDR. Gold nanoparticles (AuNPs) were first PEGylated as Au-PEG-NH₂, and DOX was then grafted onto AuNPs via a cleavable disulfide linkage (Au-PEG-SS-DOX). Confocal images revealed that the extent of intracellular uptake of Au-PEG-SS-DOX was greater than that of free DOX in the MDR cells, and inductively coupled plasma mass spectroscopy analysis further confirmed that AuNPs significantly increased the level of drug accumulation in MDR cells at a nanoparticles dose greater than 15 μM. The cytotoxicity study demonstrated that the Au-PEG-SS-DOX nanoconjugates system efficiently released the anticancer drug DOX and enhanced its cytotoxicity against MDR cancer cells. This study highlights the potential of using AuNPs for overcoming of MDR in cancer chemotherapy. Copyright © 2012 Elsevier Inc.
Original languageEnglish
Pages (from-to)204-211
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume8
Issue number2
Early online date24 Jun 2011
DOIs
Publication statusPublished - Feb 2012

Citation

Gu, Y.-J., Cheng, J., Man, C. W.-Y., Wong, W.-T., & Cheng, S. H. (2012). Gold-doxorubicin nanoconjugates for overcoming multidrug resistance. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(2), 204-211. doi: 10.1016/j.nano.2011.06.005

Keywords

  • Gold nanoparticles
  • Doxorubicin
  • Multidrug resistance
  • Chemotherapy

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