Förster resonance energy transfer studies of luminescent gold nanoparticles functionalized with ruthenium(II) and rhenium(I) complexes: Modulation via esterase hydrolysis

Frankie Chi-Ming LEUNG, Anthony Yiu-Yan TAM, Vonika Ka-Man AU, Mei-Jin LI, Vivian Wing-Wah YAM

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Abstract

A number of ruthenium(II) and rhenium(I) bipyridine complexes functionalized with lipoic acid moieties have been synthesized and characterized. Functionalization of gold nanoparticles with these chromophoric ruthenium(II) and rhenium(I) complexes has resulted in interesting supramolecular assemblies with Förster resonance energy transfer (FRET) properties that could be modulated via esterase hydrolysis. The luminescence of the metal complex chromophores was turned on upon cleavage of the ester bond linkage by esterase to reduce the efficiency of FRET quenching. The prepared nanoassembly conjugates have been characterized by transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), UV-visible spectroscopy, and emission spectroscopy. The quenching mechanism has also been studied by transient absorption and time-resolved emission decay measurements. The FRET efficiencies were found to vary with the nature of the chromophores and the length of the spacer between the donor (transition metal complexes) and the acceptor (gold nanoparticles). Copyright © 2014 American Chemical Society.

Original languageEnglish
Pages (from-to)6644-6653
JournalACS Applied Materials and Interfaces
Volume6
Issue number9
Early online date22 Apr 2014
DOIs
Publication statusPublished - 14 May 2014

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Citation

Leung, F. C.-M., Tam, A. Y.-Y., Au, V. K.-M., Li, M.-J,, & Yam, V. W.-W. (2014). Förster resonance energy transfer studies of luminescent gold nanoparticles functionalized with ruthenium(II) and rhenium(I) complexes: Modulation via esterase hydrolysis. ACS Applied Materials and Interfaces, 6(9), 6644-6653. doi: 10.1021/am500350c

Keywords

  • Esterase
  • FRET
  • Gold nanoparticles
  • Rhenium(I)
  • Ruthenium(II)
  • Transient absorption