Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents

Yung-Kang PENG, Cathy N. P. LUI, Yu-Wei CHEN, Shang-Wei CHOU, Pi-Tai CHOU, Kin Lam Ken YUNG, S. C. Edman TSANG

Research output: Contribution to journalArticlespeer-review

5 Citations (Scopus)

Abstract

Tagging recognition group(s) on superparamagnetic iron oxide is known to aid localisation (imaging), stimulation and separation of biological entities using magnetic resonance imaging (MRI) and magnetic agitation/separation (MAS) techniques. Despite the wide applicability of iron oxide nanoparticles in T 2-weighted MRI and MAS, the quality of the images and safe manipulation of the exceptionally delicate neural cells in a live brain are currently the key challenges. Here, we demonstrate the engineered manganese oxide clusters-iron oxide core-shell nanoparticle as an MR dual-modal contrast agent for neural stem cells (NSCs) imaging and magnetic manipulation in live rodents. As a result, using this engineered nanoparticle and associated technologies, identification, stimulation and transportation of labelled potentially multipotent NSCs from a specific location of a live brain to another by magnetic means for self-healing therapy can therefore be made possible. Copyright © 2017 IOP Publishing Ltd.

Original languageEnglish
Article number015102
JournalNanotechnology
Volume29
Issue number1
Early online dateDec 2017
DOIs
Publication statusPublished - 2018

Citation

Peng, Y.-K., Lui, C. N. P., Chen, Y.-W., Chou, S.-W., Chou, P.-T., Yung, K. K. L., & Tsang, S. C. E. (2017). Engineered core-shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents. Nanotechnology, 29(1), Article 015102. https://doi.org/10.1088/1361-6528/aa96eb

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