Methods: From 1992 to 1997, 15410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α-fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.
Results: Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti-hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti-HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti-HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti-HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.
Conclusions: Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases. Copyright © 2002 Blackwell Publishing Asia Pty Ltd.
|Journal||Journal of Gastroenterology and Hepatology (Australia)|
|Publication status||Published - 2002|
CitationTai, D.-I., Chen, C.-H., Chang, T.-T., Chen, S.-C., Liao, L.-Y., Kuo, C.-H., . . . Sung, J.-L. (2002). Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection. Journal of Gastroenterology and Hepatology, 17(6), 682-689. doi: 10.1046/j.1440-1746.2002.02747.x
- Familial tendency
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma