Effects of thrombin on the neurovascular unit in cerebral ischemia

Hui CAO, Sai Wang SETO, Deep Jyoti BHUYAN, Hoi Huen CHAN, Wenting SONG

Research output: Contribution to journalArticlespeer-review

10 Citations (Scopus)

Abstract

Cerebral ischemia is a cerebrovascular disease with high morbidity and mortality that poses a significant burden on society and the economy. About 60% of cerebral ischemia is caused by thrombus, and the formation of thrombus proceeds from insoluble fibrin, following its transformation from liquid fibrinogen. In thrombus-induced ischemia, increased permeability of the blood–brain barrier (BBB), followed by the extravasation of blood components into the brain results in an altered brain microenvironment. Changes in the brain microenvironment affect brain function and the neurovascular unit (NVU), the working unit of the brain. Recent studies have reported that coagulation factors interact with the NVU and its components, but the specific function of this interaction is highly speculative and warrants further investigations. In this article, we reviewed the role of coagulation factors in cerebral ischemia and the role of coagulation factors in thrombosis. Additionally, the influence of thrombin on the NVU is introduced, as well as in the function of NVU, which may help to explore part of brain injury mechanism during ischemia. Lastly, we propose some novel therapeutic approaches on ischemic stroke by reducing the risk of coagulation. Copyright © 2021 The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Original languageEnglish
Pages (from-to)973-984
JournalCellular and Molecular Neurobiology
Volume42
Early online dateJan 2021
DOIs
Publication statusPublished - May 2022

Citation

Cao, H., Seto, S. W., Bhuyan, D. J., Chan, H. H., & Song, W. (2022). Effects of thrombin on the neurovascular unit in cerebral ischemia. Cellular and Molecular Neurobiology, 42, 973-984. https://doi.org/10.1007/s10571-020-01019-6

Keywords

  • Coagulation
  • Thrombin
  • Cerebral ischemia
  • Neurovascular unit
  • Thrombus
  • Mechanism

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