Early cognitive domain deficits in patients with aneurysmal subarachnoid hemorrhage correlate with functional status

George Kwok Chu WONG, Sandy Wai LAM, Adrian WONG, Karine NGAI, Chung Tong Vincent MOK, Wai Sang POON

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Objective: Cognitive deficits commonly occur after aneurysmal subarachnoid hemorrhage (aSAH), although a few studies systemically evaluate its early impact. We hypothesized that early cognitive domain deficits in patients with aSAH correlate with functional status. Methods: We carried out a prospective observational study in Hong Kong, for which patients with aSAH, aged 21–75 years, who had been admitted within 96 h of ictus were recruited. The cognitive assessment used was the domain-specific neuropsychological assessment battery at 2–4 weeks (n = 74) after ictus. Functional status was measured using the modified Rankin Scale (mRS) and the Lawton Instrumental Activity of Daily Living (IADL) scale. The study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193). Results: Unfavorable outcome (mRS 3–5) was associated with visuospatial memory domain deficit and language domain deficit. Dependent IADL (score <15) was associated with language domain deficit. Interpretation: Visuospatial memory and language are important determinants of early functional status. Whether early targeted rehabilitation can improve functional status should be assessed in a future study. Copyright © 2016 Springer International Publishing Switzerland.
Original languageEnglish
Title of host publicationIntracranial pressure and brain monitoring XV
EditorsBeng-Ti ANG
Place of PublicationSwitzerland
PublisherSpringer International Publishing
Pages129-132
ISBN (Print)9783319225326, 9783319225333
DOIs
Publication statusPublished - 2016

Citation

Wong, G. K. C., Lam, S. W., Wong, A., Ngai, K., Mok, V., & Poon, W. S. (2016). Early cognitive domain deficits in patients with aneurysmal subarachnoid hemorrhage correlate with functional status. In B.-T. Ang (Ed.), Intracranial pressure and brain monitoring XV (pp. 129-132). Switzerland: Springer International Publishing.

Keywords

  • Cognition
  • Language
  • Memory
  • Stroke
  • Subarachnoid hemorrhage

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