Dual esterase- and steroid-responsive energy transfer modulation of ruthenium(II) and rhenium(I) complex functionalized gold nanoparticles

Frankie Chi-Ming LEUNG, Ka Man Vonika AU, Hai-Ou SONG, Vivian Wing-Wah YAM

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A number of adamantane-containing ruthenium(II) and rhenium(I) complexes have been synthesized, characterized, and noncovalently functionalized with β-cyclodextrin-capped gold nanoparticles (β-CD-GNPs) through the host-guest interaction between cyclodextrin and adamantane. The resultant nanoconjugates have been characterized by transmission electron microscopy (TEM), energy-dispersive X-ray analysis (EDX), and 2D ROESY 1H NMR experiments. The Förster resonance energy transfer (FRET) properties of the nanoconjugates can be modulated by both esterase-accelerated hydrolysis and competitive displacement of steroid, by monitoring the emission intensity and luminescence lifetime. The FRET efficiencies are found to vary with the nature of the chromophores and the length of the spacer between the transition metal complexes and the GNPs. This work constitutes a "proof-of-principle" assay method for the dual-functional detection of important classes of biomolecules, such as enzymes and steroids. Copyright © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original languageEnglish
Pages (from-to)16448-16454
JournalChemistry - A European Journal
Volume21
Issue number46
Early online date23 Sep 2015
DOIs
Publication statusPublished - 09 Nov 2015

Citation

Leung, F. C.‐M., Au, V. K.‐M., Song, H.‐O., & Yam, V. W.‐W. (2015). Dual esterase- and steroid-responsive energy transfer modulation of ruthenium(II) and rhenium(I) complex functionalized gold nanoparticles. Chemistry - A European Journal, 21(46), 16448-16454. doi: 10.1002/chem.201501808

Keywords

  • Esterase
  • Gold nanoparticles
  • Rhenium
  • Ruthenium
  • Steroids

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