Dietary exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans via fish consumption and dioxin-like activity in fish determined by H4IIE-luc bioassay

Janet Kit Yan CHAN, Yu Bon MAN, Guan Hua XING, Sheng Chun WU, Margaret B. MURPHY, Ying XU, Ming Hung WONG

Research output: Contribution to journalArticles

3 Citations (Scopus)

Abstract

Dietary exposure to polychlorinated dibenzo. -p-dioxins and dibenzofurans (PCDD/Fs) via fish consumption in two major electronic (e) waste sites: Guiyu (GY), Guangdong Province and Taizhou (TZ), Zhejiang Province, and dioxin-like activity in fish determined by H4IIE-luc bioassay. In the present study, all fish were below EU's maximum allowable concentration in muscle of fish (4. pg WHO-TEQ/g wet wt), except crucian (4.28. pg WHO-TEQ/g wet wt) and silver carps (7.49. pg WHO-TEQ/g wet wt) collected from GY rivers. Moreover, the residual concentration in bighead carp collected from GY (2.15. pg WHO-TEQ/g wet wt) was close to the EU's action level (3. pg WHO-TEQ/g wet wt) which gives "early warning" to the competent authorities and operators to take measures to eliminate contamination. In addition, results indicated that the maximum human intake of PCDD/Fs via freshwater fish consumption in GY was 4.31. pg WHO-TEQ/kg bw/day, which exceeds the higher end of the tolerable daily intake recommended by the WHO, EC-SCF and JECFA (1-4, 2 and 2.3. pg WHO-TEQ/kg bw/day respectively). Furthermore, H4IIE-luc cell bioassay provides a very sensitive and cost-efficient screening tool for assessing the overall dioxin-like toxicity in the study, and is therefore valuable for high-throughput environmental monitoring studies. Copyright © 2012 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)1192-1200
JournalScience of the Total Environment
Volume463-464
Early online dateSep 2012
DOIs
Publication statusPublished - Oct 2013

Citation

Chan, J. K. Y., Man, Y. B., Xing, G. H., Wu, S. C., Murphy, M. B., Xu, Y., & Wong, M. H. (2013). Dietary exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans via fish consumption and dioxin-like activity in fish determined by H4IIE-luc bioassay. Science of The Total Environment, 463-464, 1192-1200. doi: 10.1016/j.scitotenv.2012.07.099

Keywords

  • PCDD/Fs
  • Electronic waste
  • Estimated daily intake
  • H4IIE-luc cell bioassay
  • Freshwater fish

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