Depressive and anxiety symptoms are related to decreased lateral prefrontal cortex functioning during cognitive control in older people

Some studies have found a relationship between negative emotional symptoms and decreased lateral PFC functioning during a cognitive control task in healthy younger adults. Here, we asked whether this relationship is also present in the general older population and across different functional domains of the lateral PFC. Thirty-six older people (13 males) self-reported their recent depressive and anxiety symptoms. They also took two cognitive control tasks known to differentially engage the lateral frontoparietal network (digit n-back task) and the lateral frontotemporal network (Category Fluency Test) while hemodynamic changes in the PFC were monitored by functional near-infrared spectroscopy (fNIRS). Both depressive and anxiety symptoms were associated with decreased activation in the bilateral lateral PFC during cognitive control performance. Interestingly, these relationships were driven by the n-back task. Our findings suggest that depressive and anxiety symptoms are related to decreased lateral PFC functioning in particular domains of cognitive control among older people. Copyright © 2021 Elsevier B.V. All rights reserved.