Correlates of insight with symptomatology and executive function in patients with first-episode schizophrenia-spectrum disorder: A longitudinal perspective

Sherry Kit Wa CHAN, Ka Shing Kevin CHAN, Christy Lai HUI, Gloria Hoi Yan WONG, Wing Chung CHANG, Edwin Ho Ming LEE, Jennifer Yee Man TANG, Eric Yu Hai CHEN

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Abstract

The present study aimed to examine the relationships of insight with symptomatology and executive function, both cross-sectionally and longitudinally in patients with first-episode schizophrenia-spectrum disorders. Ninety-two medication-naïve patients were recruited and 71 completed the assessments. Insight, symptoms and executive function were assessed at baseline, 6 months and 1 year. Insight was measured with the abridged version of Scale of Unawareness of Mental Disorder (SUMD). Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Executive function was measured with the Modified Wisconsin Card Sorting Test (MCST). The most significant improvement of insight and symptomatology was found over the first 6 months, whereas the perseverative errors of MCST were significantly improved between 6 and 12 months. Differential correlations of perseverative errors of the MCST and PANSS scores with SUMD were found at different time points. This suggests the involvement of different mechanisms in insight deficit at different stages of the illness. The baseline MCST perseverative errors were correlated significantly with the SUMD total score at 6 months and the change of SUMD scores over the first 6 months. Although the variance explained was small, it suggests better set-shifting capacity facilitates the improvement of insight at an early stage of the illness. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)177-184
JournalPsychiatry Research
Volume216
Issue number2
Early online date07 Dec 2013
DOIs
Publication statusPublished - May 2014

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Executive Function
Mental Disorders
Schizophrenia

Bibliographical note

Chan, S. K. W., Chan, K. K. S., Hui, C. L., Wong, G. H. Y., Chang, W. C., Lee, E. H. M., Tang, J. Y. M., & Chen, E. Y. H. (2014). Correlates of insight with symptomatology and executive function in patients with first-episode schizophrenia-spectrum disorder: A longitudinal perspective. Psychiatry Research, 216, 177-184. doi: 10.1016/j.psychres.2013.11.028.

Keywords

  • Insight
  • First-episode schizophrenia spectrum disorder
  • Executive function
  • Symptomatology